Ulcerative colitis is one of the two major forms of inflammatory bowel disease which has unforeseeable clinical course, marked by a chronic inflammation of the colon and remission of the disease. The treatment of Ulcerative colitis is managed by the administration of anti-inflammatory or immunosuppressive drugs that are ingested orally. However, the efficacy of the drug via oral route remains unclear as the release of drugs takes place in the upper gastrointestinal tract that allows inadequate amount of drug release to the colon thereby causing various adverse effects. Therefore, the advancement of disease targeted drug delivery strategies offers numerous gains over non-targeting by granting more effective therapy and diminishing the systemic adverse effect. In this review, we investigate and discuss various approaches that assist in targeting mechanism of the respective drugs to the colon for the hindrance and management of colonic ailments.