Nicotine, not a carcinogen per se, is one of the most addictive substances known. Tobacco smoke contains a vast number of chemicals with important biological effects in disease processes. Tobacco use is a global epidemic and the adverse health conditions including cardio-vascular diseases, atherosclerosis, and cancer are the manifestations of sustained tobacco consumption. Cancer is a major public health burden in both developed and developing countries. Tuibur, considered as ‘smokeless’ tobacco product in Mizoram, is presumed as one of the “safe” nicotine delivery media. In this mini-review, few tobacco-specific carcinogens detected in tuibur solution and their potential effects on biological systems are discussed.